This is the English letter we have made for physicians to give to their patients. You can use the Google translator tool (see side bar) to make an automated translation to your own language. Please be aware that the automated Google translator is not perfect and may make errors!

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Concerns: ______________________

Date of birth: ______________________

Dear colleague,

Because of cardiologic and/or genetic evidence of Brugada syndrome in the patient mentioned above, I advised him/her not to take the following prescriptions:

DRUGS TO BE AVOIDED

Antiarrhythmic drugs*: Ajmaline, Allapinin, Ethacizin, Flecainide, Pilsicainide, Procainamide, Propafenone

Psychotropic drugs: Amitriplyline, Clomipramine, Desipramine, Lithium, Loxapine, Nortriptyline, Oxcarbazepine, Trifluoperazine

Anesthetics / analgesics*: Bupivacaine, Procaine, Propofol

Other substances: Acetylcholine, Alcohol (toxicity), Cannabis, Cocaine, Ergonovine

* For advice please visit www.brugadadrugs.org/emergencies

DRUGS PREFERABLY AVOIDED

Antiarrhythmic drugs: Amiodarone, Cibenzoline, Disopyramide, Lidocaine*, Propranolol, Verapamil, Vernakalant

Psychotropic drugs: Bupropion, Carbamazepine, Clotiapine, Cyamemazine, Dosulepine, Doxepine, Fluoxetine, Fluvoxamine, Imipramine, Lamotrigine, Maprotiline, Paroxetine, Perphenazine, Phenytoin, Thioridazine

Anesthetics / analgesics: Ketamine, Tramadol

Other substances: Demenhydrinate, Diphenhydramine, Edrophonium, Indapamide, Metoclopramide, Terfenadine/Fexofenadine

* Lidocaine use for local anesthesia (e.g. by dentists) does seem to be safe if the amount administrated is low and if it is combined with adrenaline (epinephrine) which results in a local effect only.

Further, in case of fever, close (electrocardiographic) monitoring is appropriate in combination with lowering of the body temperature (e.g. by using Paracetamol/Acetaminophen).

Please be aware of the active drugs in medicines that contain a combination of drugs. Further, the presence or absence of a particular drug on this list do not preclude a certain harmful or safe use of that particular drug in this patient respectively.

For the most recent recommendations (and the disclaimer) on drugs to be avoided by Brugada syndrome patients, please visit https://www.brugadadrugs.org .

Sincerely yours,

___________________________